1 Introduction to Research & Analysis Reports
1.1 Knockout Mouse Models Market Definition
1.2 Market Segments
1.2.1 Market by Type
1.2.2 Market by Application
1.3 Global Knockout Mouse Models Market Overview
1.4 Features & Benefits of This Report
1.5 Methodology & Sources of Information
1.5.1 Research Methodology
1.5.2 Research Process
1.5.3 Base Year
1.5.4 Report Assumptions & Caveats
2 Global Knockout Mouse Models Overall Market Size
2.1 Global Knockout Mouse Models Market Size: 2022 VS 2029
2.2 Global Knockout Mouse Models Revenue, Prospects & Forecasts: 2018-2029
2.3 Global Knockout Mouse Models Sales: 2018-2029
3 Company Landscape
3.1 Top Knockout Mouse Models Players in Global Market
3.2 Top Global Knockout Mouse Models Companies Ranked by Revenue
3.3 Global Knockout Mouse Models Revenue by Companies
3.4 Global Knockout Mouse Models Sales by Companies
3.5 Global Knockout Mouse Models Price by Manufacturer (2018-2023)
3.6 Top 3 and Top 5 Knockout Mouse Models Companies in Global Market, by Revenue in 2022
3.7 Global Manufacturers Knockout Mouse Models Product Type
3.8 Tier 1, Tier 2 and Tier 3 Knockout Mouse Models Players in Global Market
3.8.1 List of Global Tier 1 Knockout Mouse Models Companies
3.8.2 List of Global Tier 2 and Tier 3 Knockout Mouse Models Companies
4 Sights by Product
4.1 Overview
4.1.1 By Type – Global Knockout Mouse Models Market Size Markets, 2022 & 2029
4.1.2 KO
4.1.3 cKO
4.2 By Type – Global Knockout Mouse Models Revenue & Forecasts
4.2.1 By Type – Global Knockout Mouse Models Revenue, 2018-2023
4.2.2 By Type – Global Knockout Mouse Models Revenue, 2024-2029
4.2.3 By Type – Global Knockout Mouse Models Revenue Market Share, 2018-2029
4.3 By Type – Global Knockout Mouse Models Sales & Forecasts
4.3.1 By Type – Global Knockout Mouse Models Sales, 2018-2023
4.3.2 By Type – Global Knockout Mouse Models Sales, 2024-2029
4.3.3 By Type – Global Knockout Mouse Models Sales Market Share, 2018-2029
4.4 By Type – Global Knockout Mouse Models Price (Manufacturers Selling Prices), 2018-2029
5 Sights by Application
5.1 Overview
5.1.1 By Application – Global Knockout Mouse Models Market Size, 2022 & 2029
5.1.2 Metabolic Disease Mouse Models
5.1.3 Neurodegenerative Disease Mouse Models
5.1.4 Rare Disease Mouse Models
5.1.5 Spontaneous Tumor Mouse Models
5.1.6 Other
5.2 By Application – Global Knockout Mouse Models Revenue & Forecasts
5.2.1 By Application – Global Knockout Mouse Models Revenue, 2018-2023
5.2.2 By Application – Global Knockout Mouse Models Revenue, 2024-2029
5.2.3 By Application – Global Knockout Mouse Models Revenue Market Share, 2018-2029
5.3 By Application – Global Knockout Mouse Models Sales & Forecasts
5.3.1 By Application – Global Knockout Mouse Models Sales, 2018-2023
5.3.2 By Application – Global Knockout Mouse Models Sales, 2024-2029
5.3.3 By Application – Global Knockout Mouse Models Sales Market Share, 2018-2029
5.4 By Application – Global Knockout Mouse Models Price (Manufacturers Selling Prices), 2018-2029
6 Sights by Region
6.1 By Region – Global Knockout Mouse Models Market Size, 2022 & 2029
6.2 By Region – Global Knockout Mouse Models Revenue & Forecasts
6.2.1 By Region – Global Knockout Mouse Models Revenue, 2018-2023
6.2.2 By Region – Global Knockout Mouse Models Revenue, 2024-2029
6.2.3 By Region – Global Knockout Mouse Models Revenue Market Share, 2018-2029
6.3 By Region – Global Knockout Mouse Models Sales & Forecasts
6.3.1 By Region – Global Knockout Mouse Models Sales, 2018-2023
6.3.2 By Region – Global Knockout Mouse Models Sales, 2024-2029
6.3.3 By Region – Global Knockout Mouse Models Sales Market Share, 2018-2029
6.4 North America
6.4.1 By Country – North America Knockout Mouse Models Revenue, 2018-2029
6.4.2 By Country – North America Knockout Mouse Models Sales, 2018-2029
6.4.3 US Knockout Mouse Models Market Size, 2018-2029
6.4.4 Canada Knockout Mouse Models Market Size, 2018-2029
6.4.5 Mexico Knockout Mouse Models Market Size, 2018-2029
6.5 Europe
6.5.1 By Country – Europe Knockout Mouse Models Revenue, 2018-2029
6.5.2 By Country – Europe Knockout Mouse Models Sales, 2018-2029
6.5.3 Germany Knockout Mouse Models Market Size, 2018-2029
6.5.4 France Knockout Mouse Models Market Size, 2018-2029
6.5.5 U.K. Knockout Mouse Models Market Size, 2018-2029
6.5.6 Italy Knockout Mouse Models Market Size, 2018-2029
6.5.7 Russia Knockout Mouse Models Market Size, 2018-2029
6.5.8 Nordic Countries Knockout Mouse Models Market Size, 2018-2029
6.5.9 Benelux Knockout Mouse Models Market Size, 2018-2029
6.6 Asia
6.6.1 By Region – Asia Knockout Mouse Models Revenue, 2018-2029
6.6.2 By Region – Asia Knockout Mouse Models Sales, 2018-2029
6.6.3 China Knockout Mouse Models Market Size, 2018-2029
6.6.4 Japan Knockout Mouse Models Market Size, 2018-2029
6.6.5 South Korea Knockout Mouse Models Market Size, 2018-2029
6.6.6 Southeast Asia Knockout Mouse Models Market Size, 2018-2029
6.6.7 India Knockout Mouse Models Market Size, 2018-2029
6.7 South America
6.7.1 By Country – South America Knockout Mouse Models Revenue, 2018-2029
6.7.2 By Country – South America Knockout Mouse Models Sales, 2018-2029
6.7.3 Brazil Knockout Mouse Models Market Size, 2018-2029
6.7.4 Argentina Knockout Mouse Models Market Size, 2018-2029
6.8 Middle East & Africa
6.8.1 By Country – Middle East & Africa Knockout Mouse Models Revenue, 2018-2029
6.8.2 By Country – Middle East & Africa Knockout Mouse Models Sales, 2018-2029
6.8.3 Turkey Knockout Mouse Models Market Size, 2018-2029
6.8.4 Israel Knockout Mouse Models Market Size, 2018-2029
6.8.5 Saudi Arabia Knockout Mouse Models Market Size, 2018-2029
6.8.6 UAE Knockout Mouse Models Market Size, 2018-2029
7 Manufacturers & Brands Profiles
7.1 The Jackson Laboratory
7.1.1 The Jackson Laboratory Company Summary
7.1.2 The Jackson Laboratory Business Overview
7.1.3 The Jackson Laboratory Knockout Mouse Models Major Product Offerings
7.1.4 The Jackson Laboratory Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.1.5 The Jackson Laboratory Key News & Latest Developments
7.2 Charles River Laboratories
7.2.1 Charles River Laboratories Company Summary
7.2.2 Charles River Laboratories Business Overview
7.2.3 Charles River Laboratories Knockout Mouse Models Major Product Offerings
7.2.4 Charles River Laboratories Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.2.5 Charles River Laboratories Key News & Latest Developments
7.3 Taconic Biosciences
7.3.1 Taconic Biosciences Company Summary
7.3.2 Taconic Biosciences Business Overview
7.3.3 Taconic Biosciences Knockout Mouse Models Major Product Offerings
7.3.4 Taconic Biosciences Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.3.5 Taconic Biosciences Key News & Latest Developments
7.4 Envigo
7.4.1 Envigo Company Summary
7.4.2 Envigo Business Overview
7.4.3 Envigo Knockout Mouse Models Major Product Offerings
7.4.4 Envigo Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.4.5 Envigo Key News & Latest Developments
7.5 Janvier Labs
7.5.1 Janvier Labs Company Summary
7.5.2 Janvier Labs Business Overview
7.5.3 Janvier Labs Knockout Mouse Models Major Product Offerings
7.5.4 Janvier Labs Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.5.5 Janvier Labs Key News & Latest Developments
7.6 GemPharmatech
7.6.1 GemPharmatech Company Summary
7.6.2 GemPharmatech Business Overview
7.6.3 GemPharmatech Knockout Mouse Models Major Product Offerings
7.6.4 GemPharmatech Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.6.5 GemPharmatech Key News & Latest Developments
7.7 GenOway
7.7.1 GenOway Company Summary
7.7.2 GenOway Business Overview
7.7.3 GenOway Knockout Mouse Models Major Product Offerings
7.7.4 GenOway Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.7.5 GenOway Key News & Latest Developments
7.8 Applied StemCell
7.8.1 Applied StemCell Company Summary
7.8.2 Applied StemCell Business Overview
7.8.3 Applied StemCell Knockout Mouse Models Major Product Offerings
7.8.4 Applied StemCell Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.8.5 Applied StemCell Key News & Latest Developments
7.9 Fred Hutch
7.9.1 Fred Hutch Company Summary
7.9.2 Fred Hutch Business Overview
7.9.3 Fred Hutch Knockout Mouse Models Major Product Offerings
7.9.4 Fred Hutch Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.9.5 Fred Hutch Key News & Latest Developments
7.10 Mary Lyon Centre
7.10.1 Mary Lyon Centre Company Summary
7.10.2 Mary Lyon Centre Business Overview
7.10.3 Mary Lyon Centre Knockout Mouse Models Major Product Offerings
7.10.4 Mary Lyon Centre Knockout Mouse Models Sales and Revenue in Global (2018-2023)
7.10.5 Mary Lyon Centre Key News & Latest Developments
8 Global Knockout Mouse Models Production Capacity, Analysis
8.1 Global Knockout Mouse Models Production Capacity, 2018-2029
8.2 Knockout Mouse Models Production Capacity of Key Manufacturers in Global Market
8.3 Global Knockout Mouse Models Production by Region
9 Key Market Trends, Opportunity, Drivers and Restraints
9.1 Market Opportunities & Trends
9.2 Market Drivers
9.3 Market Restraints
10 Knockout Mouse Models Supply Chain Analysis
10.1 Knockout Mouse Models Industry Value Chain
10.2 Knockout Mouse Models Upstream Market
10.3 Knockout Mouse Models Downstream and Clients
10.4 Marketing Channels Analysis
10.4.1 Marketing Channels
10.4.2 Knockout Mouse Models Distributors and Sales Agents in Global
11 Conclusion
12 Appendix
12.1 Note
12.2 Examples of Clients
12.3 Disclaimer

List of Tables
Table 1. Key Players of Knockout Mouse Models in Global Market
Table 2. Top Knockout Mouse Models Players in Global Market, Ranking by Revenue (2022)
Table 3. Global Knockout Mouse Models Revenue by Companies, (US$, Mn), 2018-2023
Table 4. Global Knockout Mouse Models Revenue Share by Companies, 2018-2023
Table 5. Global Knockout Mouse Models Sales by Companies, (K Units), 2018-2023
Table 6. Global Knockout Mouse Models Sales Share by Companies, 2018-2023
Table 7. Key Manufacturers Knockout Mouse Models Price (2018-2023) & (US$/Unit)
Table 8. Global Manufacturers Knockout Mouse Models Product Type
Table 9. List of Global Tier 1 Knockout Mouse Models Companies, Revenue (US$, Mn) in 2022 and Market Share
Table 10. List of Global Tier 2 and Tier 3 Knockout Mouse Models Companies, Revenue (US$, Mn) in 2022 and Market Share
Table 11. By Type – Global Knockout Mouse Models Revenue, (US$, Mn), 2022 & 2029
Table 12. By Type - Global Knockout Mouse Models Revenue (US$, Mn), 2018-2023
Table 13. By Type - Global Knockout Mouse Models Revenue (US$, Mn), 2024-2029
Table 14. By Type - Global Knockout Mouse Models Sales (K Units), 2018-2023
Table 15. By Type - Global Knockout Mouse Models Sales (K Units), 2024-2029
Table 16. By Application – Global Knockout Mouse Models Revenue, (US$, Mn), 2022 & 2029
Table 17. By Application - Global Knockout Mouse Models Revenue (US$, Mn), 2018-2023
Table 18. By Application - Global Knockout Mouse Models Revenue (US$, Mn), 2024-2029
Table 19. By Application - Global Knockout Mouse Models Sales (K Units), 2018-2023
Table 20. By Application - Global Knockout Mouse Models Sales (K Units), 2024-2029
Table 21. By Region – Global Knockout Mouse Models Revenue, (US$, Mn), 2022 VS 2029
Table 22. By Region - Global Knockout Mouse Models Revenue (US$, Mn), 2018-2023
Table 23. By Region - Global Knockout Mouse Models Revenue (US$, Mn), 2024-2029
Table 24. By Region - Global Knockout Mouse Models Sales (K Units), 2018-2023
Table 25. By Region - Global Knockout Mouse Models Sales (K Units), 2024-2029
Table 26. By Country - North America Knockout Mouse Models Revenue, (US$, Mn), 2018-2023
Table 27. By Country - North America Knockout Mouse Models Revenue, (US$, Mn), 2024-2029
Table 28. By Country - North America Knockout Mouse Models Sales, (K Units), 2018-2023
Table 29. By Country - North America Knockout Mouse Models Sales, (K Units), 2024-2029
Table 30. By Country - Europe Knockout Mouse Models Revenue, (US$, Mn), 2018-2023
Table 31. By Country - Europe Knockout Mouse Models Revenue, (US$, Mn), 2024-2029
Table 32. By Country - Europe Knockout Mouse Models Sales, (K Units), 2018-2023
Table 33. By Country - Europe Knockout Mouse Models Sales, (K Units), 2024-2029
Table 34. By Region - Asia Knockout Mouse Models Revenue, (US$, Mn), 2018-2023
Table 35. By Region - Asia Knockout Mouse Models Revenue, (US$, Mn), 2024-2029
Table 36. By Region - Asia Knockout Mouse Models Sales, (K Units), 2018-2023
Table 37. By Region - Asia Knockout Mouse Models Sales, (K Units), 2024-2029
Table 38. By Country - South America Knockout Mouse Models Revenue, (US$, Mn), 2018-2023
Table 39. By Country - South America Knockout Mouse Models Revenue, (US$, Mn), 2024-2029
Table 40. By Country - South America Knockout Mouse Models Sales, (K Units), 2018-2023
Table 41. By Country - South America Knockout Mouse Models Sales, (K Units), 2024-2029
Table 42. By Country - Middle East & Africa Knockout Mouse Models Revenue, (US$, Mn), 2018-2023
Table 43. By Country - Middle East & Africa Knockout Mouse Models Revenue, (US$, Mn), 2024-2029
Table 44. By Country - Middle East & Africa Knockout Mouse Models Sales, (K Units), 2018-2023
Table 45. By Country - Middle East & Africa Knockout Mouse Models Sales, (K Units), 2024-2029
Table 46. The Jackson Laboratory Company Summary
Table 47. The Jackson Laboratory Knockout Mouse Models Product Offerings
Table 48. The Jackson Laboratory Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 49. The Jackson Laboratory Key News & Latest Developments
Table 50. Charles River Laboratories Company Summary
Table 51. Charles River Laboratories Knockout Mouse Models Product Offerings
Table 52. Charles River Laboratories Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 53. Charles River Laboratories Key News & Latest Developments
Table 54. Taconic Biosciences Company Summary
Table 55. Taconic Biosciences Knockout Mouse Models Product Offerings
Table 56. Taconic Biosciences Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 57. Taconic Biosciences Key News & Latest Developments
Table 58. Envigo Company Summary
Table 59. Envigo Knockout Mouse Models Product Offerings
Table 60. Envigo Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 61. Envigo Key News & Latest Developments
Table 62. Janvier Labs Company Summary
Table 63. Janvier Labs Knockout Mouse Models Product Offerings
Table 64. Janvier Labs Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 65. Janvier Labs Key News & Latest Developments
Table 66. GemPharmatech Company Summary
Table 67. GemPharmatech Knockout Mouse Models Product Offerings
Table 68. GemPharmatech Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 69. GemPharmatech Key News & Latest Developments
Table 70. GenOway Company Summary
Table 71. GenOway Knockout Mouse Models Product Offerings
Table 72. GenOway Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 73. GenOway Key News & Latest Developments
Table 74. Applied StemCell Company Summary
Table 75. Applied StemCell Knockout Mouse Models Product Offerings
Table 76. Applied StemCell Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 77. Applied StemCell Key News & Latest Developments
Table 78. Fred Hutch Company Summary
Table 79. Fred Hutch Knockout Mouse Models Product Offerings
Table 80. Fred Hutch Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 81. Fred Hutch Key News & Latest Developments
Table 82. Mary Lyon Centre Company Summary
Table 83. Mary Lyon Centre Knockout Mouse Models Product Offerings
Table 84. Mary Lyon Centre Knockout Mouse Models Sales (K Units), Revenue (US$, Mn) and Average Price (US$/Unit) (2018-2023)
Table 85. Mary Lyon Centre Key News & Latest Developments
Table 86. Knockout Mouse Models Production Capacity (K Units) of Key Manufacturers in Global Market, 2021-2023 (K Units)
Table 87. Global Knockout Mouse Models Capacity Market Share of Key Manufacturers, 2021-2023
Table 88. Global Knockout Mouse Models Production by Region, 2018-2023 (K Units)
Table 89. Global Knockout Mouse Models Production by Region, 2024-2029 (K Units)
Table 90. Knockout Mouse Models Market Opportunities & Trends in Global Market
Table 91. Knockout Mouse Models Market Drivers in Global Market
Table 92. Knockout Mouse Models Market Restraints in Global Market
Table 93. Knockout Mouse Models Raw Materials
Table 94. Knockout Mouse Models Raw Materials Suppliers in Global Market
Table 95. Typical Knockout Mouse Models Downstream
Table 96. Knockout Mouse Models Downstream Clients in Global Market
Table 97. Knockout Mouse Models Distributors and Sales Agents in Global Market
List of Figures
Figure 1. Knockout Mouse Models Segment by Type in 2022
Figure 2. Knockout Mouse Models Segment by Application in 2022
Figure 3. Global Knockout Mouse Models Market Overview: 2022
Figure 4. Key Caveats
Figure 5. Global Knockout Mouse Models Market Size: 2022 VS 2029 (US$, Mn)
Figure 6. Global Knockout Mouse Models Revenue, 2018-2029 (US$, Mn)
Figure 7. Knockout Mouse Models Sales in Global Market: 2018-2029 (K Units)
Figure 8. The Top 3 and 5 Players Market Share by Knockout Mouse Models Revenue in 2022
Figure 9. By Type - Global Knockout Mouse Models Revenue, (US$, Mn), 2022 & 2029
Figure 10. By Type - Global Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 11. By Type - Global Knockout Mouse Models Sales Market Share, 2018-2029
Figure 12. By Type - Global Knockout Mouse Models Price (US$/Unit), 2018-2029
Figure 13. By Application - Global Knockout Mouse Models Revenue, (US$, Mn), 2022 & 2029
Figure 14. By Application - Global Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 15. By Application - Global Knockout Mouse Models Sales Market Share, 2018-2029
Figure 16. By Application - Global Knockout Mouse Models Price (US$/Unit), 2018-2029
Figure 17. By Region - Global Knockout Mouse Models Revenue, (US$, Mn), 2022 & 2029
Figure 18. By Region - Global Knockout Mouse Models Revenue Market Share, 2018 VS 2022 VS 2029
Figure 19. By Region - Global Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 20. By Region - Global Knockout Mouse Models Sales Market Share, 2018-2029
Figure 21. By Country - North America Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 22. By Country - North America Knockout Mouse Models Sales Market Share, 2018-2029
Figure 23. US Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 24. Canada Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 25. Mexico Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 26. By Country - Europe Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 27. By Country - Europe Knockout Mouse Models Sales Market Share, 2018-2029
Figure 28. Germany Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 29. France Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 30. U.K. Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 31. Italy Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 32. Russia Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 33. Nordic Countries Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 34. Benelux Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 35. By Region - Asia Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 36. By Region - Asia Knockout Mouse Models Sales Market Share, 2018-2029
Figure 37. China Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 38. Japan Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 39. South Korea Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 40. Southeast Asia Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 41. India Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 42. By Country - South America Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 43. By Country - South America Knockout Mouse Models Sales Market Share, 2018-2029
Figure 44. Brazil Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 45. Argentina Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 46. By Country - Middle East & Africa Knockout Mouse Models Revenue Market Share, 2018-2029
Figure 47. By Country - Middle East & Africa Knockout Mouse Models Sales Market Share, 2018-2029
Figure 48. Turkey Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 49. Israel Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 50. Saudi Arabia Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 51. UAE Knockout Mouse Models Revenue, (US$, Mn), 2018-2029
Figure 52. Global Knockout Mouse Models Production Capacity (K Units), 2018-2029
Figure 53. The Percentage of Production Knockout Mouse Models by Region, 2022 VS 2029
Figure 54. Knockout Mouse Models Industry Value Chain
Figure 55. Marketing Channels

※参考情報 ノックアウトマウスモデルは、特定の遺伝子が機能しないように作成されたマウスを用いた研究モデルです。このモデルは、遺伝子の役割を理解するための強力なツールとして広く利用されています。遺伝子のノックアウトとは、特定の遺伝子を取り除く、またはその機能を無効化することを指します。ノックアウトマウスモデルを作成することで、研究者はその遺伝子が生物学的プロセスや疾患に及ぼす影響を直接的に調べることができます。 ノックアウトマウスモデルの特徴としては、まず、遺伝子の機能を失わせることができる点があります。これにより、特定の遺伝子の役割を明らかにすることが可能になります。また、ノックアウトマウスは、哺乳類としての生理的特徴を持っているため、ヒトの生理学や病理学を理解する上での良いモデルとなります。さらに、ノックアウトマウスは、様々な遺伝子をターゲットにすることができるため、複雑な疾患メカニズムの解析にも有用です。 ノックアウトマウスモデルには、いくつかの種類があります。代表的なのは「完全ノックアウト」と「条件付きノックアウト」です。完全ノックアウトは、対象の遺伝子が全ての細胞で機能しないように設計されているモデルです。これにより、遺伝子の全体的な影響を調べることができます。一方、条件付きノックアウトは、特定の細胞タイプや発生段階でのみ遺伝子の機能を失わせることができるモデルです。この方法では、遺伝子の影響をより細かいレベルで分析することが可能になります。 ノックアウトマウスの用途は多岐にわたります。研究分野としては、発生学、神経科学、免疫学、癌研究などがあります。具体的には、特定の遺伝子がどのようにして疾患を引き起こすかを研究するために使用されます。例えば、がん関連遺伝子のノックアウトマウスを用いることで、新しい治療法や予防策の開発に寄与することができます。また、神経科学の分野では、神経伝達物質や神経回路の研究において、特定の神経受容体やイオンチャネルのノックアウトマウスが利用されています。これにより、神経疾患のメカニズムを理解し、新たな治療方法の開発が進められています。 ノックアウトマウスモデルを作成するための関連技術も重要です。一般的には、遺伝子編集技術であるCRISPR-Cas9が広く利用されています。この技術は、標的遺伝子を正確に切断し、ノックアウトを行うことが可能です。CRISPR-Cas9は、従来のノックアウト技術に比べて迅速かつ効率的であるため、研究者にとって非常に有用です。また、同様に、遺伝子組換え技術やトランスジェニック技術も併せて使用されることがあります。 ノックアウトマウスモデルの利点は多いですが、いくつかの限界も存在します。まず、ノックアウトによって生じる表現型は、必ずしも遺伝子の機能を捉えるものではない場合があります。また、ヒトの疾病モデルとして使用する際には、マウスとヒトの間には多くの生物学的な違いがあるため、結果の解釈には慎重さが求められます。さらに、ノックアウトにより生じる compensatory mechanisms（補償機構）により、予想外の表現型が現れることもあります。 総じて、ノックアウトマウスモデルは、遺伝子機能の解明や疾病理解に対する貴重な手段であり、効率的な遺伝子編集技術の発展により、ますますその可能性は拡大しています。研究者たちは、このモデルを使用して新しい発見を続けており、医療や生物学の分野において大きな進展をもたらすことが期待されています。ノックアウトマウスモデルは、今後も研究の重要な一環として、様々な課題に立ち向かうための基盤を提供し続けるでしょう。

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