1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 End User Analysis
3.7 Emerging Markets
3.8 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global Small Molecule Drug Discovery Market, By Therapeutic Area
5.1 Introduction
5.2 Oncology
5.3 Central Nervous System
5.4 Cardiovascular
5.5 Respiratory
5.6 Metabolic Disorders
5.7 Gastrointestinal
5.8 Other Therapeutic Areas
6 Global Small Molecule Drug Discovery Market, By Process/Phase
6.1 Introduction
6.2 Target ID/Validation
6.3 Hit Generation and Selection
6.4 Lead Identification
6.5 Lead Optimization
7 Global Small Molecule Drug Discovery Market, By End User
7.1 Introduction
7.2 Pharmaceutical&biotechnology companies
7.3 Academic Institutes
8 Global Small Molecule Drug Discovery Market, By Geography
8.1 Introduction
8.2 North America
8.2.1 US
8.2.2 Canada
8.2.3 Mexico
8.3 Europe
8.3.1 Germany
8.3.2 UK
8.3.3 Italy
8.3.4 France
8.3.5 Spain
8.3.6 Rest of Europe
8.4 Asia Pacific
8.4.1 Japan
8.4.2 China
8.4.3 India
8.4.4 Australia
8.4.5 New Zealand
8.4.6 South Korea
8.4.7 Rest of Asia Pacific
8.5 South America
8.5.1 Argentina
8.5.2 Brazil
8.5.3 Chile
8.5.4 Rest of South America
8.6 Middle East & Africa
8.6.1 Saudi Arabia
8.6.2 UAE
8.6.3 Qatar
8.6.4 South Africa
8.6.5 Rest of Middle East & Africa
9 Key Developments
9.1 Agreements, Partnerships, Collaborations and Joint Ventures
9.2 Acquisitions & Mergers
9.3 New Product Launch
9.4 Expansions
9.5 Other Key Strategies
10 Company Profiling
10.1 21st Century Therapeutics Inc.
10.2 Gilead Sciences Inc.
10.3 BioNTech (4SC-Discovery )
10.4 Bristol-Myers Squibb Company
10.5 Acacia Pharma Gr
10.6 AstraZeneca
10.7 Agilent Technologies Inc.
10.8 Boehringer Ingelheim GmbH
10.9 GlaxoSmithKline PLC
10.10 Takeda Pharmaceutical Industries Ltd
10.11 Johnson & Johnson
10.12 Pfizer Inc.
10.13 Merck KGaA
10.14 Novartis
10.15 Teva Pharmaceuticals
List of Tables
Table 1 Global Small Molecule Drug Discovery Market Outlook, By Region (2020-2028) ($MN)
Table 2 Global Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 3 Global Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 4 Global Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 5 Global Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 6 Global Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 7 Global Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 8 Global Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 9 Global Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 10 Global Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 11 Global Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 12 Global Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 13 Global Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 14 Global Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 15 Global Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 16 Global Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 17 Global Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
Table 18 North America Small Molecule Drug Discovery Market Outlook, By Country (2020-2028) ($MN)
Table 19 North America Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 20 North America Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 21 North America Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 22 North America Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 23 North America Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 24 North America Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 25 North America Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 26 North America Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 27 North America Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 28 North America Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 29 North America Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 30 North America Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 31 North America Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 32 North America Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 33 North America Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 34 North America Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
Table 35 Europe Small Molecule Drug Discovery Market Outlook, By Country (2020-2028) ($MN)
Table 36 Europe Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 37 Europe Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 38 Europe Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 39 Europe Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 40 Europe Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 41 Europe Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 42 Europe Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 43 Europe Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 44 Europe Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 45 Europe Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 46 Europe Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 47 Europe Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 48 Europe Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 49 Europe Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 50 Europe Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 51 Europe Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
Table 52 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Country (2020-2028) ($MN)
Table 53 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 54 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 55 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 56 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 57 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 58 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 59 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 60 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 61 Asia Pacific Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 62 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 63 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 64 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 65 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 66 Asia Pacific Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 67 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 68 Asia Pacific Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
Table 69 South America Small Molecule Drug Discovery Market Outlook, By Country (2020-2028) ($MN)
Table 70 South America Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 71 South America Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 72 South America Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 73 South America Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 74 South America Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 75 South America Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 76 South America Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 77 South America Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 78 South America Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 79 South America Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 80 South America Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 81 South America Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 82 South America Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 83 South America Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 84 South America Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 85 South America Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
Table 86 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Country (2020-2028) ($MN)
Table 87 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Therapeutic Area (2020-2028) ($MN)
Table 88 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Oncology (2020-2028) ($MN)
Table 89 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Central Nervous System (2020-2028) ($MN)
Table 90 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Cardiovascular (2020-2028) ($MN)
Table 91 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Respiratory (2020-2028) ($MN)
Table 92 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Metabolic Disorders (2020-2028) ($MN)
Table 93 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Gastrointestinal (2020-2028) ($MN)
Table 94 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Other Therapeutic Areas (2020-2028) ($MN)
Table 95 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By By Process/Phase (2020-2028) ($MN)
Table 96 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Target ID/Validation (2020-2028) ($MN)
Table 97 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Hit Generation and Selection (2020-2028) ($MN)
Table 98 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Lead Identification (2020-2028) ($MN)
Table 99 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Lead Optimization (2020-2028) ($MN)
Table 100 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By By End User (2020-2028) ($MN)
Table 101 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Pharmaceutical&biotechnology companies (2020-2028) ($MN)
Table 102 Middle East & Africa Small Molecule Drug Discovery Market Outlook, By Academic Institutes (2020-2028) ($MN)
| ※参考情報 低分子創薬（Small Molecule Drug Discovery）は、主に分子量が500以下の小さな化合物をターゲットとした創薬プロセスのことを指します。これらの低分子薬は、通常、細胞内の特定のタンパク質と相互作用することで、生物学的な効果を発揮します。これにより、病気の治療や予防が可能になります。 低分子薬の種類としては、抗がん剤、抗菌剤、抗ウイルス剤、抗炎症薬、神経系疾患に対する薬剤などが挙げられます。抗がん剤は、がん細胞の分裂を阻害することで、その増殖を抑える作用があります。抗菌剤や抗ウイルス剤は、微生物やウイルスの増殖を防ぐために使用され、これによって感染症の治療が行われます。また、抗炎症薬は、炎症反応を抑制することにより、様々な疾患の症状を軽減します。神経系障害に対する低分子薬は、パーキンソン病やアルツハイマー病などの神経変性疾患に対して効果を示すことがあります。 低分子創薬のプロセスは通常、以下の段階で構成されます。最初に、ターゲットの選定が行われます。これは、特定の疾患に関連する生物学的プロセスを理解し、そこに関与するタンパク質や酵素を特定することから始まります。次に、高スループットスクリーニング（HTS）を用いて、小さな化合物ライブラリから候補となる化合物を見つけ出します。この段階では、数百万もの化合物を一度に評価できる技術が活用されます。 候補化合物が選定されると、リード化合物の最適化へ進みます。このプロセスでは、化合物の構造を変化させながら、親和性や選択性、薬物動態（ADMET: 吸収、分布、代謝、排泄、毒性）などの特性を評価します。最終的な段階では、前臨床試験や臨床試験を経て、効果や安全性が確認された化合物が新薬として承認を受け、市場に出ることになります。 関連技術としては、コンピュータ支援ドラッグデザイン（CADD）が重要な役割を果たしています。CADDは、分子モデリングやシミュレーションを通じて、化合物の設計や最適化に貢献しており、これにより創薬の効率を高めることができます。また、バイオインフォマティクスや高スループットスクリーニングの進展により、ターゲットの特定や化合物のスクリーニングも迅速かつ精密に行えるようになっています。 さらに、薬物送達システムの技術も欠かせません。低分子薬はその特性上、体内での吸収や分布に影響されやすいため、ナノテクノロジーやリポソーム、などの技術を用いて、薬物のバイオアベイラビリティを向上させる研究が進められています。これにより、より効果的に治療を行うことができるようになります。 低分子創薬は、従来の薬剤とは異なり、ターゲット選択性の高い治療を可能とし、副作用を抑えることが期待されています。また、新たな疾患や耐性菌の出現に対しても、迅速に対応するための柔軟なアプローチとしても注目されています。今後、人工知能や機械学習を利用した創薬プロセスの最適化が進むことで、さらなる革新が期待されており、創薬の未来を担う重要な分野となっていくでしょう。 |
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